A key spokesman for the medical establishment against the antivivisection movement, Walter B. Cannon was head of the Council for the Defence of Medical Research of the American Medical Association from 1908 to 1936. He and his colleague William W. Keen monitored antivivisectionist activity, mobilized the medical profession, lobbied politicians, testified in public hearings, and wrote tirelessly in defense of animal experimentation. Cannon was George Higginson Professor of Physiology at Harvard Medical School and head of its physiology department. Keen was a prominent surgeon and neurologist from Philadelphia. The Cannon Papers consist of over 1.5 linear feet of correspondence, 1905-1928, primarily between Cannon (1871-1945) and Keen (1837-1932) regarding their mutual opposition to the antivivisection movement.

The bacteriologist and virologist Thomas Milton Rivers spent over thirty years at the Rockefeller Institute as a researcher in the Department of Bacteriology and from 1937-1955, as Director. Working on measles and pneumonia, Rivers discovered the parainfluenzae bacillus and cultivated vaccine virus for human use, and during the 1950s, he played an important role in coordinating research on poliomyelitis as head of the National Institute for Infantile Paralysis. During the Second World War, Rivers led the Naval Medical Research Unit in the South Pacific, rising to the rank of Rear Admiral. The Rivers Papers contains correspondence, laboratory notes, speeches, and photographs documenting Rivers' activities at the Rockefeller Institute, the development of polio vaccine, and Rivers' Navy experience in the Pacific during World War II.

Victor George Heiser, who was a preeminent public health physician, created a rich archive of material documenting all phases of his career, especially the international health work of the Rockefeller Foundation from 1915-1934. There are voluminous, detailed, and interesting diaries for the whole course of his adult life (1890-1972). There are notebooks reflecting on his early training and work (1890-1907), and lectures he attended at Jefferson Medical College in Philadelphia (1897).

Correspondence, notebooks, research data related to Cole's career as the first director at the Hospital of the Rockefeller Institute of Medical Research, 1908-1937. His research of pneumonia was conducted when the disease was epidemic. Personal correspondence reflect Cole's life as a medical resident at Johns Hopkins, 1899-1908. Documented are his memberships in leading medical organizations throughout his career, including the Association of American Physicians and the New York Academy of Medicine. This collection showcases the evolving changes in the medical profession from practicing physician to clinician.

Working on the Army Epidemiological Board in the 1940s, Joseph Stokes, Jr. discovered the value of gamma globulin for the prevention of epidemic hepatitis. His subsequent research included immunization against influenza, protection against poliomyelitis by gamma globulin, antigenic difference between epidemic and serum hepatitis, immunization procedures in mumps, development of a vaccine against measles. His clinical focus was on the causes and prevention of childhood infectious diseases. His administrative work includes the transformation of Children's Hospital of Philadelphia and the University of Pennsylvania, School of Medicine, Department of Pediatrics. His community work consists of public health and environment control issues.

One of the most influential statisticians of the twentieth century, John Wilder Tukey (1915-2000) played a key role in both the development and study of statistics. Upon receiving his Ph.D. in mathematics in 1939 from Brown University, he joined the faculty at Princeton; in 1945, he also began work at Bell Laboratories. Equally committed to both Princeton and Bell Labs, Tukey chose to work concurrently at both institutions. He was also a consultant for many companies, such as Merck and Company, Xerox Corporation, and the Educational Testing Service, and was a frequent advisor to the government for such programs as the US Census. From 1960 to 1980 he led the statistical component of NBC's election night projections. Among other projects Tukey analyzed Alfred Kinsey's research and examined data on ozone depletion. Tukey made many important contributions to the field of statistics, such as work in time series analysis, exploratory data analysis, and multiple comparisons. Through his work, Tukey developed statistical applications including the Box-and-Whisker Plot, the Stem-and-Leaf Diagram, Cooley-Tukey Fast Fourier Transforms, Tukey's Paired Comparisons and citation and permutated indices. Tukey's influence extends beyond statistics to everyday language: he was the first to use the word "software" in print and coined words such as "bit" and "linear programming." A prolific writer, John W. Tukey penned more than 500 technical papers and reports and published, among numerous other works. His collected papers amount to eight volumes of work. The Tukey Papers provides a comprehensive perspective into Tukey's professional activities from his days as a graduate student until his death in 2000. Among the material is his correspondence and his published and unpublished works. There is abundant material from Tukey's long careers at Bell Laboratories and Princeton University, including extensive lecture notes and syllabi. Also included are copious materials relating to his professional activities with such agencies as the National Research Council, the Army Records Office, Xerox PARC, Merck and Company, the President's Science Advisory Committee, and the National Academy of Sciences.